The reference to
http://support.apple.com/kb/HT4079 by Mr. Brewer sounds great. However, I believe the referenced article has not been updated for iTunes 10. It specifically references iTunes 9 and related apps.
I suspect iTunes10 has tweaked the backup and syncing functions but will continue to seek apple support help to determine this. The referenced file path in the for-mentioned article (Mac: ~/Library/Application Support/MobileSync/Backup/) doesn't exist on my machine. Using Spotlight to find anything "Backup" on my machine also resulted in a dead end.
On a positive note, the previous posting referencing the app "BackOff" (which is free BTW) worked for me. I also had to reboot my ipad to get it to perform a manual backup which it completed today (first time in several weeks). This was confirmed by the indication in the iTunes>Preferences>Devices window.
My guess is that the backup is filed in some obscure binary system folder. Has anyone else located it?