Having the same problem here.. what does this error mean?

I am also experiencing the same issue as of September 12, 2012. Anytime I attempt to check for software updates, I end up with the error message:

An error has occurred

The operation couldn’t be completed.

(NSURLErrorDomain error - 1100.)

I am not sure if there is something we as users can do on our end, or if it’s a technical issue on Apple’s end with their servers.

Hey, guys! I have the same problem. In the morning everything was fine. But at 12.00 I began to receive this error.

Having the same problem! anyone knows what to do?Thanks

LOTS of people are receiving this error (including myself). It probably has nothing to do with your computer at all but the fact that Apple's servers probably weren't prepared for the massive numbers of attemped updates. DNS fixes have been posted, but these don't work for me. Unfortunately, probably the best solution is either to wait or, if you're looking for the update to iTunes, go to: http://support.apple.com/downloads/ where you can find the latest software.

Same error for me.  When 39 hours without emails nw I can access the App Store.....

same problem here in my mid 2010 macbook pro    NSURLErrorDomain error -1100    when i want to update

Same problem here in Lima, Peru

Hi guys, i had the same problem till few minutes ago when i try to flush DNS cache to resolve the problem and it works for me!!! How to do this? It's simple:

Open terminal and copy and paste this command

sudo killall -HUP mDNSResponder

It will ask your password, insert it and press enter, that's all!

Didn't solve nothing for me... problem continues...

Same error here for the last 18 hours.  The killall suggestion didn't work.