I visited an Apple Store in early April to try to resolve this problem. Apparently, the voice over can be activated by randomly sliding your finger around on ANY screen, regardless of whether the feature has been turned off in the Settings. This is a feature not a bug! (Is this documented anywhere?). That plus the absence of a lock that was available on previous generations means that if you carry your ipod anywhere that anything can brush up against whatever screen you have left on top (like in your pocket) the odds are that the voice over will be activated. The Genius suggested getting a case, which he said they don't sell at the Apple Store. In theory, a case would protect the accidental movement across a screen. I contacted a case vendor before purchasing one and asked if he thought his case (with a gatefold cover) would prevent this. He said no, so I saved the money. I have been resorting to desperate measures - I cut off the end of a sock, covered the ipod with it, and loosely wrapped the speaker cord around it to keep the sock in place. This is, needless to say, a real pain and not 100% successful. However, it has reduced the occurrence of the problem, depending on what's in my pocket, whether or not I bend over, etc. It occurs slightly less frequently if I carry it in my shirt pocket and not a pants pocket. The claim is that this is for enhanced Accessibility, but there should be some way to permanently disable this feature if you NEVER want it to turn on, and also to lock the screen, so that Voice Over does not turn on AND the selection you are playing, be it podcast or music, does not change randomly. I tried various solutions, including a reset. It was easy enough to reload all of my podcasts, but reloading any music that was NOT from iTunes was also problematic. I had switched to an iPod touch when my old Nano died, but this had problems of its own and so I switched to a new Nano.