Hi djfilms99,
I have a similar issue, and I share your frustration. The crosshairs recommendation you keep getting is workable, but tedious and error-prone. You need something easily repeatable.
I find that when something isn't easily repeatable in the UI, that's when Mac's being unix under the hood really shines. If you're comfortable on the command line (the Terminal app) and perhaps with a little scripting, a workaround for something like this is doable.
You need a command line utility called "convert". It's part of the imagemagick suite of tools (imagemagick.org). If your Mac didn't ship with it installed, there is a binary download on the imagemagick site. A little set up work, but if you need to do bulk work on images, totally worth it.
In my case I needed to capture images that I knew were always 320x480. The shift-command-4 spacebar capture of one of these windows came out 432x614:
$ file screengrab.png
screengrab.png: PNG image data, 432 x 614, 8-bit/color RGBA, non-interlaced
There's more extra than title bar there! There's also shadows all the way around. I figured out that the padding is 56 on left and right, 54 on top (including the title bar), and 80 pixels below. Armed with this, the convert command looks like this:
$ convert screengrab.png -crop 320x480+56+54 cropped.png
$ file cropped.png
cropped.png: PNG image data, 320 x 480, 8-bit/color RGBA, non-interlaced
Voila! If you know your image dimensions you want to trim it to (sounds like you will since you're dealing with video), just plug those dimensions in where I've got "320x480" and whatever your filenames are, and it should work.
Granted, it's quite a bit more work than just clicking on something once, but it's a LOT less work than painstakingly mouse dragging to the pixel over and over and over again. I hope this helps you!