Majority of issues which are reported here, are somehow connected with bluetooth (or technologies, using it, like Handoff, AirDrop, BT mouse, etc.).
Two variants are possible:
1) Either Apple developers, while working on all this cool new features, messed smth in underlying bluetooth/wi-fi firmware and drivers. This is unpleasant, but not fatal. In such a case it could be repaired with software update in the (nearest) future. Just report this to http://bugreport.apple.com. The more users report it - the sooner it will be sorted out.
2) Or this is some hardware issue with Wi-Fi/Bluetooth in Macs, that shows itself under heavy load of Bluetooth (e.g. encryption). Not sure, if these two use the same hardware chip, but they can at least use the same antenna. This problem was not common before, cause not so many users of MacBooks use BT devices like Mighty Mouse (and mouse can be pretty lightweight device for bluetooth to work with). And now this became "visible" problem, cause Apple rolled-out these new features in Yosemite (Continuity, Handoff, AirDrop, Instant HotSpot, etc. all using BT) which a decent number of users are trying to check. Still, I hope this is only software issue and can be fixed.