I have a 6 Plus, and this happens to me most often in the Youtube app. It sometimes happens in Safari, and occasionally in another app.
As the title says, "THIS IS NOT A REACHABILITY ISSUE" -- so double tapping home DOES NOT work.
Usually, at least with Youtube, I cannot get the problem solved without restarting the phone. It is definitely a bug, and I don't see it to be one of reachability. In Youtube and Safari, the problem SOMETIMES happens so that its a half screen similar to the look of reachability, although, parts of the screen are cut off and not reachable at that point. Sometimes it splits vertically, with only the left third of the screen showing. When you go into "full screen" on a video, you get a tiny thumbnail in the middle instead of full screen. That is consistent regardless of which symptom the problem displays. There are similar issues with Safari. I've seen it also happen in apps like Facebook where they use their own browser to present content. When it happens, there doesn't seem to be a fix except to restart. Killing the app doesn't seem to work with Youtube, and I haven't tried it with another app.