Macbook pro 13 inch el capitan always show the dead ball rainbow

Right now I'm using Macbook Air 13 inch mid 2012

I once updated my iphone 4s from ios 8.0.2 to 9.1.2 using my mac and i left the mac update this all night long

But tommorrow after I tried to run my mac, it turns very slow and I finally found out that my mac always show the dead ball rainbow once it "freeze" or "hang". I have this problem whenever I run any app, try to press any of sound, brightness, stop row buttons or even write something on spotlight

I have tried several thing to retrieve my mac

1.) I tried to quit the not responding with force quit

2.) Open up activity monitor and try to quit the app that consume so much memory or %CPU running

3.) Do the disk repair

4.) Forcefully shut down the mac by pressing the power button

5.) Try to restart by using Command + alt + shift + power button or command + R + power button before my mac turn on (and other way to turn on the mac that I don't really remember

6.) Download the app "CleanMyMac3" and clear about 100gb data

7.) I have also check my internal hardisk and find that I still have 250gb of my free space memory

Anyone have idea what should I do to make my Mac turn normal? I need fast respond asap 😟