I have this issue. I want to have a setup with
1. Bluetooth apple-wireless-keyboard
2. Bluetooth apple-wireless-trackpad
3. Bluetooth apple-wireless-mouse
4. Bluetooth Bose-Wireless-Headset (Ae2w)
I have experienced a lot of choppiness in the Audio. What I noticed if I disable all the devices other than headset (#1, #2, #3) then I dont have any choppiness.
The problem in my opinion is in the bluetooth prioritization of Audio stream over the other bluetooth streams. I am disappointed on how Apple does not cater to bluetooth audio.
Its a shame, now I use wired headsets.
I have Macbook Pro 13inch 2015, with Sierra on it.