Same issue here, Mac Pro Late 2013 (High Sierra 10.13.1)
Still able to use mouse cursor, and I've noticed that tasks that are running such as file transfers seem to complete in the background (I hear the notification) but the screen is unresponsive. Constantly having to hard reset the computer.
I've wiped the computer several times over (I've been having issues for 18 months - this is just the latest! - taking me out of my AppleCare period not that it helped me at all). After the most recent wipe I haven't even bothered to put my files back on the computer, and have only installed the bare bones of the software I need.
I was thinking about rolling back to Sierra, or... trying out the 10.13.2. Kinda dreading it though, as have lost so much time over this.
Was wondering if we have anything in common that might not be playing ball with the OS. I'll list my setup/software, it does seem to be the OS, but maybe it will help.
LG M232 Via HDMI
Apollo Twin - Thunderbolt (Latest software)
Propellerhead Reason 10 (Latest update)
Anker USB 3 Hub - Apple Wired Keyboard, Nektar Impact GX61 (unplugged), Fender Bronco Amp USB (unplugged) iLOK (I deleted the software as I noticed another user had it experiencing crashes - didn't help)
Samsung & Toshiba USB External drives (not always connected)
Fender Fuse Software (this included silverlight - had the issue before and after this) Zwift
After my clean install a week or 2 ago the Mac seemed quite calm but I did get one or two crashes, since I've gradually started installing software I've been experiencing more and more. I've tried all the ports, various things plugged in and unplugged.