I am officially no longer seeing any pauses/freezes in High Sierra, and this was even before updating to 10.13.3. The two things I did which seemed to fix the issue were as follows:
1. Followed Bone1971's recommendation to delete old entries in Library/LaunchAgents and Library/LaunchDaemon folders. I didn't delete all - just items which were obviously left over from old/outdated/unused software.
2. After making sure that my Time Machine backups were up to date (I run them to two different local backup volumes), I booted to the Recovery Partition, launched Disk Utility, deleted the boot partition, created a new boot partition, installed a clean copy of High Sierra, then restored all of my apps and profile settings.
BTW, I always use the Combo Update when updating the OS.
Things I did NOT do:
1. Update any video drivers apart from those updates supplied by Apple in Combo Updates.
2. Perform a clone or restore from a clone.
3. Swap out my Apple-supplied SSD for one from a 3rd party.
My configuration: MacBook Pro (Retina, 15-inch, Mid 2015), 2.5 GHz Intel Core i7, 16 GB 1600 MHz DDR3,
AMD Radeon R9 M370X 2 GB, Intel Iris Pro 1536 MB