MacOS Update 10.14.6 not working

Give this a try. Check and make sure that you do not have "Install macOS Mojave.app" in your Applications Folder. If you do have it drag it to the Trash and enter your administrative password to trash it. If no Mojave installer is in your Applications Folder then that is good. Now download the entire macOS 10.14.6 installer from the App Store and see if it opens. If it opens then run it. If it fails try installing in Safe Mode.

Upgrade to macOS Mojave - Official Apple Support

Use safe mode to isolate issues with your Mac - Apple Support

Seems to have been my issue as well. I plugged it directly in to the router and the update went smoothly. Cleared up all of the other issues I was having as well.

Try downloading the 10.14.6 Combo Update.

https://support.apple.com/kb/DL2010?viewlocale=en_US&locale=en_US

I suspect it was a connection, bandwidth or firewall issue for me. I have a MacBook Pro that is only a month old, with 32GB RAM and a 1TB hard drive (it's only 20% full). I could not get the update to work either at the hotel where I was staying, or at the office (where I measured up- and download speeds of 300MB / sec). I arrived home this weekend and the update worked instantly (I have a very robust connection here - 500MB / sec both up and down).

The first thing you need to do is uninstall McAfee. Macs do not need antivirus programs and they cause nothing but problems.

System updates no longer show in the App Store.

I have the same issue. I have downloaded the combination updater, which fails as it does for fasb43. I have started from Safe Boot, disconnected all external drives, don't have Install macOS Mojave.app anywhere on the internal drive; I have run Disk Utility, which finds no errors, and zapped the PRAM. Nothing helps.

This is with an almost brand-new Mac Mini running 10.14.5, with over 200 GB available on the internal drive. I have been trying for several days, at different times of the day, just in case it was the server; nothing makes any difference.

I am in the same boat here. I've tried all the suggestions listed, and still can't get the update to take. I also cannot connect to my time capsule (though Airport Utility sees it perfectly) or DVD drive, and McAfee won't update either. Not sure if these things are related, but I'm hoping to at least get the 10.14.6 update going and start from there.

Tried this. Same response (cannot validate update).

Another odd thing is that I can see the update in preferences, and I get notifications that they update is pending / ready, but the App Store doesn't show it at all.

Connecting directly to the router did not help for me.