Agreed - my audio appears to be well and truly forked... when looking at the audio preferences panel, devices appear and disappear with no apparent correlation to anything. Most recently my Sound prefs pane crashed entirely and I had to restart System Prefs to get to it:

I have found that SOMETIMES if I kill all the audio processes (using the Activity Monitor app) it will restore things; sometimes I just need to shut down and restart.
I thought maybe this had to do with the audio output in my HDMI monitor (which I turned off on the monitor, but it still shows up as an option)... but it has started happening even when I am not using any external devices.
Apple, you guys REALLY need to do something about this. In a world where working remotely is the norm and we need to take all of our meetings via video conference, having flaky or non-working audio is a deal breaker. I REALLY don't want to have to downgrade the OS, or worse leverage my old Windows machine - please fix this.