@hexsus
That is a tough situation to be in, I feel for you. That is an awesome eGPU enclosure! You may try and contact Mantiz and see if they have any advice. If you haven't already, you might also try removing the GPU and disconnecting anything plugged into IO ports to see if the box will power your laptop without issues. I've seen builds posted with very similar setup to yours, so it should be possible to get this working.
https://egpu.io/forums/builds/2018-13-inch-macbook-pro-8th4cu-rx-580-32-gbps-tb3-mantiz-saturn-pro-v2-macos-11-1-windows-10-20h2-quiet-mods/
One option is to try is a clean install. This is a pain IMO, and Apple has made it somewhat more difficult with the last couple OSs. I've had success resolving issues in the past doing a clean install and I'm close to doing one if I encounter more severe issues.
Also, when working with Apple Support, make sure you're up-to-date with the latest version of Big Sur 11.2.3. It's doubtful this will help your issue, but I've experienced Apple Support dismissing my ticket if I wasn't running the latest update.
If possible, purchase and try a different eGPU Case/solution like something from the Apple Store that is on their compatibility list. Use an external graphics processor with your Mac - Apple Support
You could buy one of the cheap options Apple offers and then return it after testing. If you encounter issues with one of Apples eGPU options, create a Support Ticket and it should get more attention.
The intent would be to determine if your computer is encountering issues or if the issue stems from the eGPU.
This is of course a gamble and a lot of work. I fully understand your Mantiz box is compatible with Macs, but Apple Support may dismiss a case if there is an external/third party peripheral they do not support.
Good luck! Post again if you find a solution.
@pLlave
Interesting thought and suggestion about PowerMS, I was curious about this and did try various combos of ports and power sources. Unfortunately it did not help. An update was pushed the same day and that didn't help either.
Fortunately I'm only having issues when using the Menubar's disconnect option. If I close apps and just unplug the eGPU, I don't have issues, just get that silly notification to "Safely disconnect..."
Will post again if I have any updates. If anyone does some deep digging on the net and finds some obscure solution, I would love to hear about it.