From the EtreCheck report:
Minor Issues:
These issues do not need immediate attention but they may indicate future problems or opportunities for improvement.
No Time Machine backup - Time Machine backup not found.
Configuration profiles found - This computer may have configuration profiles installed. These are sometimes used by adware and malware.
Apps crashing - There have been numerous app crashes.
Clean up - There are orphan files that could be removed.
Unsigned files - There are unsigned software files installed. Apple has said that unsigned software will not run by default in a future version of the operating system.
System modifications - There are a large number of system modifications running in the background.
Kernel extensions present - This computer has kernel extensions that may not work in the future.
Sharing enabled - This computer has sharing services enabled that could be a security risk.
Remove the Configuration Profile, you have not installed knowingly.
https://support.apple.com/guide/mac-help/configuration-profiles-standardize-settings-mh35561/mac
Temporarily disable TrendMicro and test, even though it is found in the legitimate list and probably OK.