Dear Missy5937
Sorry to tell you but you completely missed the point. In our cases, the trackpad and/or mouse still work perfectly, can select different windows, click everywhere and so on.
The problem lies in pop-up windows (as in "save as" for a document) as well most of the System Preferences windows* are irresponsive to the clicks. Those two types of windows refuse any input. The Tab key is often our only resort to interact with such windows.
For most "save as" and similar dialog boxes, resizing them (each one, each time) somehow allows mouse input again, which is a good but annoying workaround to this problem. However, as the System Preferences windows cannot be resized, many systems cannot be reached. The "lock changes" button is by the way not the cause as this one cannot be clicked either.
*only System preferences responding to the mouse clicks in my case :
- Mission control
- Spotlight
- Trackpad
- Displays
This makes it difficult to update my mac, as, well, the Software Update menu is not in the above list...
By the way, I am running BigSur 15.5.2 on an M1 chip macbook pro 13 inch.
In the hope this helps the support in identifying the bug,