Mojave 2021-003 security update seems to have affected Graphics card compatibility
Has anyone using a Radeon RX580 in a Mac Pro 5,1 found boot problems since the last security update? I have found that my machine will only boot if you hold alt cmd P R on start up. After spending some time eliminating other possible issues I removed the RX580 and refitted the original ATI card and it then booted normally.
If I am right then hopefully Apple will restore the compatible drivers for the RX580 in another update.
I have another Mac Pro 5,1 of exactly the same spec which has not had the security update and it continues to boot normally.