Big Sur "You do not have permission to open the application..."

This helped me for my canon printer, perhaps it could still work for your epson scanner driver?

https://support.usa.canon.com/kb/index?page=content&id=ART180175&actp=search&viewlocale=en_US&searchid=1627865485743

I am having the same problem. Keep getting You do not have permission to open the application “EPSON Scanner.app”.

I can print just fine but get this message when trying to scan. I have gone and downloaded all the latest software from Epson still nothing. What did Epson tell you?

I wrote them an hour ago. Nothing yet. Will let you know what I hear, but if they get emails from a lot of people they might be more likely to address the problem. Here is the contact form:

https://epson.custhelp.com/app/ask/p_model_name/Epson%20Perfection%20V37

Did you try Camp_mothers solution? (it's from Cannon but I tried it and it worked!!!)

https://support.usa.canon.com/kb/index?page=content&id=ART180175&actp=search&viewlocale=en_US&searchid=1627865485743

I have a similar problem with a HP printer. I have to physically crawl under my desk and unplug and plug in the power cable to get the printer to work. In this last “upgrade” the workaround from HP does not work. Can’t afford another printer at this point, “unemployed and on a fixed income” to resolve the problem. But, with the upgrade I cannot use other Apple apps, terminal will not allow me to use “Visual Code” or switch from Terminal to Atom. I am in a fog.

Your problemS are different.

Please start your own thread and explain the issues you are having. To save time, post an Etrecheck report so people have enough information about your setup to provide specific assistance.

Afraid opening the Epson Scanner App in HD/Library/Image Capture/Devices did not work because it is a 32 bit app, so will not run in Big Sur. Done all the updates from the Epson website, including ICA driver, Epson Scan 2, Epson Scan 2 utility, etc etc. Still unable to communicate with scanner from PDF Pen Pro, Photoshop 2021 and Epson Scan 2. The latter was working but since updating to 11.5.2, it no longer works with same problems as other apps - unable to communicate with Scanner error 21345. Support from Epson non-existent - don't even bother to reply. Their instructions are very inconsistent. On one page Epson says to download and install their ICA driver and on another they say to download updates only from Apple (there are none). I am left with a very expensive Epson photo scanner (V700) as a large paper weight. Not happy. Usual buck passing going on. My suspicion is that the 700/750 scanner driver is pointing to Epson Scanner App, which will not run as 32 bit. It should be pointing to Epson Scan 2. The system will not permit adding Epson Scan 2.app to the list of devices in Image Capture in the HD library. I will try deleting some plist files and see if that will wake things up. That has worked for me in the past.

Finally success. I went into the HD/library and the User/library then preferences. I deleted every single plist file at every level that might have anything to do with a)Apple system files for scanning b)Epson scanning and scanning apps and c)Image Capture. I then restarted, which took a long time so must have been a lot of tidying up taking place. Now scanning works from Image Capture, PDF Pen Pro, Photoshop 2021 and Preview. Phew!

If you over delete plist files, don't worry as at worst they will be still sitting in the trash can but in practice, they will all re-create clean versions. Big Sur on M1 machines seem particularly prone to preference file problems. I had to do a similar job recently to get my internet to connect to all addresses. Originally it would only connect to Google. I think the DNS preferences plist file was causing a blockage.

I have the Canon MF743Cdw laser colour printer and I was having the error about permissions on the scan application as well. I found the solution was to hold the command (apple key) down while launching the app and finally the app loaded properly and I could get into the settings to control where things were saved, etc. Once I launched the app this way it remembered I allowed it and I didn't have to hold the command key down in future times. It seems that Canon and Apple need to work together to make sure Canon devices are trusted by the OSX in the future so it doesn't frustrate end users.

Thank you Craig for posting your steps! This method resolved my problem with Epson Perfection V30 scanner. Also, I suggest to connect cable directly to the Mac. I bought the Monoprice 2.0 USB-C to USB Type-B Printer Cable which allows me to connect directly to the back of my Mac and avoid any 3rd parties flimsy adapters or hubs

Craig was spot on with the path

So click on the Macintosh HD/Library/Image Capture/Devices now in here you'll find the Epson scanner app, mine is called 'EPSON ES016E.app' but yours might differ.

However, my solution was to change the EPSON permission from everyone-read to everyone-read\write and the scanner then loaded in Image Capture App.

OMG thank you - this worked for me too - after downloading and installing all sorts of other stuff...grrr...but do we know if this is a permanent(ish) fix, or do we have to do this process every time we need to scan?