Can I make an ebook using ePub with fixed pages from Quark Xpress?

Assuming QuarkXPress 2021, yes.

https://www.quark.com/pdfs/QXP_2021/en/A%20Guide%20to%20QuarkXPress%202021.pdf

Product docs: https://www.quark.com/support/documentation/quarkxpress/quarkxpress-2021/

Product support: https://support.quark.com/en/support/home

I would encourage viewing the resulting document on a variety of EPUB reader devices, to ensure that what you’re seeing on those different readers matches your expectations,

Should be able to , Choose File > Export as > ePub. Go through Dialogue box settings. Lots of videos youtube. Quarks always been a power house.