Any Third Party Applications that will interfere with the normal operation of the OS, alter, modify, remove or delete or attempt to do so is an invitation for disaster and comprising the Operating System
Any of the below should be removed as per Developers Instructions
This will include CleanMyMac Please read some of the may posting specific to this Application
What is “Other” storage on a Mac, and how can I clean it out?
Free up storage space on your Mac
OmniDiskSweeper Safe to use
GrandPerspective
How to delete Time Machine snapshots on your Mac
See used and available storage space on your Mac
Locate backups of your iPhone, iPad, and iPod touch
The final word from Apple on Managing the " Other/ System Data “ Category
Other / System Data: Contains files that don’t fall into the categories listed here. This category primarily includes files and data used by the system, such as log files, caches, VM files, and other runtime system resources. Also included are temporary files, fonts, app support files, and plug-ins. You can't manage the contents of this category. The contents are managed by macOS, and the category varies in size depending on the current state of your Mac.