The operation can’t be completed because you don’t have the necessary permission.

Those aren't users they are Groups and should be left alone. If you're not having any problems in your normal day to day operation you should ignore them.

Regular OS X users are put into the staff group. Admin users are put in the staff and admin groups. The admin group can do some things that other users cannot do. e.g. Write to the /Applications folder

The Wheel group, as in "A Big Wheel", meaning someone of importance and authority, is a group for administrators. Many files are part of the Wheel group with permissions that allow users in the Wheel group to access them, but would not allow other users without Wheel group access.

One must go into root user to get the wheel group.

Again, they are not users so leave them alone and ignore.

The De facto Admin Account is the very First Account that was used when this computer was First Setup as New.

Any account there after, can Only be administered by the Admin Account of this computer.

Only that account can Add, Remove, Elevate or Diminish any Other Account on this computer.

Set up users, guests, and groups on Mac

There are no known Windows-like Viruses in the wild that self replicate and affect macOS, because of the underling UNIX  Foundation and Permission Limitation. 

Additionally, and specific to Big Sur macOS 11 and Monterey macOS 12, the Operating System resides in a Sealed and Read Only Volume that can not be opened by the User or “ Bad Actor “ Software.

The Only thing this Antivirus software is protecting is the Bank Account of the Developers and for zero return to the User aside from the problems this software creates.

The The Built in Security  is all that is required to protect the computer.

Any Third Party Applications that will interfere with the normal operation of the OS,  is an invitation for disaster and comprising the Operating System

Any of the below should be removed as per Developers Instructions 

This will include CleanMyMac , This will include BitDefender , 

This will included Norton Antivirus ,  Sophos Av Software Please read some of the many posting regarding this Application

Intego AntiVirus, McAfee, MacKeeper, Avast AntiVirus

Ad Guard, Webroot , ESET

They are created when the system is installed and have been there from the beginning. They just don't show up at random times. They are part of the UNIX underpinnings of macOS.

What is the user attempting to achieve ?

Is this a New Issue ? If Yes, what exactly changed on this computer ?

Is this an Old Issue ? If Yes, what actions has the user taken to fix this issue ?

After all,  we do not what to suggest possible solutions for what has already been attempted by the User 

Understand, we are all working Remotely from all around the world. 

Therefore, we do not have the On-Hands experience the User ( you ) has with this computer.

Reliable , accurate, details and context will really help to pinpoint a possible solution.

You are welcome 🇨🇦

Do come back to the Apple Support Communities ( ASC )  in the future, if / or when additional questions may arise

Opps! Missed P. Phillips response regarding Sophos and other unneeded types of apps.