I got this info about the calibration issue from some other sources when researching this. I saw this post and it makes sense.
Hi, I'd just like to report that I've experienced this problem intermittently as well and after researching it, there may be a problem with the touch screen's calibration. I haven't been able to figure out when or how the screen is calibrated, but from experience, it seems to re-calibrate itself upon waking up from sleep. By having a finger or hand pressing on the screen accidentally when waking up the phone, the calibration could be so far off that your finger is not recognized on the screen. As a first step, try to leave your phone screen pointed away from your leg in your pocket and avoid touching the screen when someone calls.
and again here:
I am going to poke at this some more, as I am getting the same issue.
As far as I can tell, when the unlock button is pressed/a call comes in, the screen gets calibrated. However, sometimes this calibration seems to be off, and everything does not respond to touch.