Thank you for posting your EtreCheck report.
I think most things look pretty good.
Your Apple SSD has plenty of free space available (646.71 GB).
Your SSD Write and Read speeds look good at 2980/3020 MB/s.
Your 16 GB of RAM may be under pressure and EtreCheck reports there is "heavy RAM usage". You can check if your Mac needs more RAM with the Activity Monitor app.
I do see a few things that concern, one in particular - CMM:
1) CleanMyMac – This is a big red flag. If you search these Apple Communities you'll find plenty of users who have experienced similar problems that were ultimately attributed to this software. CMM is considered akin to malware on the Mac by many veteran users. You would do well to uninstall CMM per the publisher's guidance, then restart your Mac and run it for a time without. See if that has any impact on the issue.
2) DuetDisplay – Though not usually a problem per se, I question whether you need to have it loaded and/or running on the laptop. If you're using it, then leave it. If you don't use it, it wouldn't be a bad idea to uninstall it as there is a small chance that it may be in conflict with the macOS video drivers.
3) Parallels – running? The same goes for Parallels as for DuetDisplay. If you don't actively use it you may consider uninstalling it. The app has crashed 16 times in the past 60 days.
Likewise for any other third-party applications that you have installed. If you have installed app that you eventually find you don't use, uninstall them per developer's guidance. Keep note of any registration info in case you decide to reinstall later.
Address these things and also those items that EtreCheck reports as "Minor Issues:".
You can manage the orphan files and the unsigned files from within the EtreCheck app.
