My Imac has become really slow and impossible to work on

This shows two strikes against you:

Drives:

disk0 - CT1000BX500SSD1 1.00 TB (Solid State - TRIM: No)

Internal SATA 6 Gigabit Serial ATA

First, the Crucial BX500 has not proved to be a reliable drive in some Macs. Their newer MX series is excellent.

Second, you must enable TRIMforce on the SSD to get full performance. These drive speed disparities in your second report:

Performance:

System Load: 43.01 (1 min ago) 14.13 (5 min ago) 5.38 (15 min ago)

Nominal I/O usage: 282.08 MB/s

File system: 26.42 seconds

Write speed: 78 MB/s ⚠️ 👈🏻

Read speed: 445 MB/s 👈🏻

are classic for an SATA6 drive without TRIM enabled. Been there—suffered that.

Your Read speeds are close to nominals—which are about 460-500MB/sec for an SATA6 SSD attached to the Fusion hard drive bus. However, the Writes are abysmal. When TRIM is not engaged, Writes start to degrade in speed relative to reads; after a time, Writes can fall to 1/2 of Reads or less. When it happened to me, the Writes fell to about 60MB/sec before onee of the wise contributors here clued my into the TRIM issue.

NOTE: the maker of the drive I used (OWC) said TRIM was not necessary on that model. After about three years of normal use I found it was very necessary!

Your installer should have known to engage TRIM.

Fortunately you don't have to pack a big iMac back to the the installer; you can engage TRIM yourself, but it is a PROCESS, not an instant fix:

First see this article on how to engage TRIM on that drive: How to Execute ‘Trimforce’ Command with Your SSD

That is the fast part. The next takes time. To get the drive to fully work with TRIM engaged, you must do a Safe Mode boot several times. I found I had to let the Mac "soak" in Safe Mode for 30-60 minutes several times to allow Safe Mode to complete all it had to accomplish. Eventually the Reads and Writes speeds achieved parity and continues to delivery nominal speeds in the 480-500MB/sec range for over four years.

Hopefully my bad experience and its fix will help your iMac get better. However, note that an SATA6 internal SSD can never as fast as a healthy FUSION drive in that iMac model.

• Write speed: 3 MB/s
• Read speed: 43 MB/

Yikes!!!

You can use Drive DX to possibly get a better view of Drive health…

https://binaryfruit.com/drivedx

Delete these files & restart...

/Library/LaunchAgents/com.adobe.AAM.Updater-1.0.plist

~/Library/LaunchAgents/com.adobe.ARM.***.plist

~ tilde indicates your home folder

Apple hid the Users' Library folders...

Method 1:

1 From the Finder, select the Go menu at top of the screen, and choose Go to Folder.

2 In the window that opens, enter ~/Library, and click Go.

Or…

Use the Command-Shift-period

Uninstall CleanMyMac per their directions , then run etrecheck again to see what chaff it left...

On CMM…

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+1 to using DriveDX to check the health of your dirves.

You have far to many third-party App's and Processes running on the poor old iMac.

1) Totally uninstall CleanMyMac.

2) Use Safari or FireFox instead of the resource hog Google Chrome.

3) Go to System Preferences > Users & Groups > Login Items and remove all third-party app's.

4) Then only open the App's and/or Processes that you need to work in and quit those App's when you are done.

Could just be to many App's and background processes running at the same time.

To get a good look at what might be causing slowness and other issues,

Download and run the free version of EtreCheckPro, from > https://etrecheck.com/en/index.html

Then post the Report, as per > How to use the Add Text Feature When Post… - Apple Community

Well, better but Writes really slow till..

Write speed: 78 MB/s

Read speed: 445 MB/s

In Terminal paste this command & press enter then copy Y paste the results here,,,

diskutil list

Also, You can use Drive DX to possibly get a better view of Drive health…

https://binaryfruit.com/drivedx

Good eye Allan.