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Macos Sequoia 15.0 and office 365 - not responding

Since installing macOS Sequoia (15.0), I've had a problem when I open a Microsoft Word, Excel and PowerPoint file with Office 365 (latest version 16.89). The application doesn't respond. I have to force it to quit and open again: MS Word opened the file correctly. I've reinstalled Office several times, but the problem persists. In general, I can open one file, then application not responding.

Mac Studio, macOS 14.7

Posted on Sep 25, 2024 7:49 AM

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Question marked as Top-ranking reply

Posted on Oct 31, 2024 7:20 PM

Since the latest MacOS Sequoia 15.0 upgrade for the past few months, this "not responding" situation has made my life ****. Even the latest MacOS Sequoia 15.1 doesn't change that nightmare situation. Don't know who is responsible for this; Apple or Microsoft, but we end users are victims :-( Please Help!

66 replies

Nov 25, 2024 10:01 AM in response to PhMil

I had the same issue - I deleted and reinstalled, created new users as well as all other suggestions. Finally, I went to the Genius bar and they told me to turn off Auto Save in Excel. In Word, uncheck ALL option in Save Options, and restart the computer. It has been 2 weeks and it appears to be working ok.

Dec 5, 2024 7:49 AM in response to earchide

This worked for me: Open the Terminal and run the following commands:

/System/Library/Frameworks/CoreServices.framework/Versions/A/Frameworks/LaunchServices.framework/Versions/A/Support/lsregister -kill -r -domain local -domain system -domain user 


sudo /System/Library/Frameworks/CoreServices.framework/Frameworks/LaunchServices.framework/Support/lsregister -kill -seed -lint -r -f -v -dump -domain local -domain system -domain user -domain network


killall Dock

Macos Sequoia 15.0 and office 365 - not responding

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