I updated to 10.4.5 shortly after I got my iMac set up -- the problem I have is that after using the Mighty Mouse for a while, my "Button 1" actions quit; it starts acting like my Button 2 (giving me the contextual menus inside windows, not activating icons in the Dock, not letting me click links in my browser, etc.). I end up going into the System Preferences and reselecting everything, and that seems to clear it up, but it's a bit annoying.
My Mighty Mouse setup is: left side Primary Button (Left-click), right-side Secondary Button (right-click), side buttons Dashboard, and scroll button Off (I had that button as Dashboard but was giving me some problems).