An invalid response was received from the device?

If you read the post just above yours, you will see what the problem is. You need OS X 10.9.5 or higher, and iTunes 12.5.1 to be able to sync a phone with iOS 10. Unless you can update your OS X, you will not be able to sync the device.

Apple is not here, and if you are not running iTunes 12.5 or higher, then that is why you are getting the response. You need to be running iTunes 12.5 or higher in order for iTunes to recognize an iOS 10 device. Even if it says your iTunes is up to date, you need to check the version. It may be as up to date as it can get with your OS version, but if it is not 12.5, then it is not up to date enough....

GB

Update your iTunes. But not through iTunes but go to your browser and download the setup program to ensure you have the latest version of iTunes.

Same thing happened to me and I re installed the latest iTunes from the apple site and it fixed the problem

I found that, starting with iTunes 12.3, iTunes no longer recognizes 1st generation iPod Touch devices running the standard IOS from Apple you have to load some after-market firmware like this from Felixbruns http://www.felixbruns.de/iPod/firmware/.

You can find the instructions here iTunes 12.3 issue with iPod Touch

very simple fix. I kept having this happen to me and i tried all of the options down below. What i simply did was reset my network settings on the phone.

Reset network settings:

Settings>General>reset>reset network settings.

allow it to restart and then plug it back into the computer.

Good luck!

apple is no God, Lawrence.

ran into this problem with a customer today, and per this suggestion, was chasing my tail in circles reinstalling Windows 7 USB drivers, checking BIOS, options, and other stuff. The phone is not jailbroken in any way.

Turns out it was iTunes. It needed to be updated, yet again. Typical apple giving completely unhelpful error messages.

Apparently Apple has finally heard us. Software update for my OS-X 10.8.5, Mountain Lion, showed a update available. When I installed the update, which did not change the OS revision number, it rev'd iTunes to 12.4.1.1 and the iPone started syncing properly.

To get it working again, I had to uninstall all Apple device applications from my machine and re-install iTunes. I had an iPhone 5 that would sync and an iPhone 6 that wouldn't. It was a major pain in the arse, and is not caused by fidget USB ports as Apple tried to tell me.

An invalid response was received from the device?

I found a solution... even though iTunes says its up to date its not.

Update iTunes to version 12.5 instead of 12.1 and it will solve this issue immediately, or at least it did for me after 3 days of searching for a solution to this issue

If your phone is not jailbroken restore it using iTunes.

uninstall the iTunes from laptop and reinstall it and it is done. 100% works. Happened with me after upgrading to ios 10

I updated the iMac's OS X to El Capitan and it solved the issue. Thanks for the help.

If you are running Windows, the latest version if iTunes to run correctly is 12.5.1 or higher, the latest is 12.5.3. You also need Windows 7 or above.

Did you read my post above yours? DO you have iTunes 12.5.1 installed? It requires OS X 10.9.5 or above.

Just as another side note, Kaspersky is one of the worse anti-virus softwares to work with iTunes and other Apple software and devices. If you were to search this forum, you would find numerous issues with it, and it does make it very difficult when it comes to updating iOS. You will usually have to disable it to accomplish the task. There are settings in Kaspersky that allow for ignoring iTunes and other Apple software but it doesn't always work. Keep this in mind when it comes time to update iOS on the phone. Glad everything else is working now.