An invalid response was received from the device?

I found that, starting with iTunes 12.3, iTunes no longer recognizes 1st generation iPod Touch devices running the standard IOS from Apple you have to load some after-market firmware like this from Felixbruns http://www.felixbruns.de/iPod/firmware/.

You can find the instructions here iTunes 12.3 issue with iPod Touch

very simple fix. I kept having this happen to me and i tried all of the options down below. What i simply did was reset my network settings on the phone.

Reset network settings:

Settings>General>reset>reset network settings.

allow it to restart and then plug it back into the computer.

Good luck!

apple is no God, Lawrence.

ran into this problem with a customer today, and per this suggestion, was chasing my tail in circles reinstalling Windows 7 USB drivers, checking BIOS, options, and other stuff. The phone is not jailbroken in any way.

Turns out it was iTunes. It needed to be updated, yet again. Typical apple giving completely unhelpful error messages.

Having same problem. Using iMac. Running Lion. Tried different usb cables, no success. Backed the my iPhone 6S Plus with the first usb cable on Sept. 3, 2016 anticipating the new IOS. Any idea???

I experienced the same issue with an iPad and iPhone SE just after updating their OS to v10.

The computer I was attempting to sync was an All-in-One Desktop running Mac OS X v 10.6.8.

madmage816 wrote:

I experienced the same issue with an iPad and iPhone SE just after updating their OS to v10.

The computer I was attempting to sync was an All-in-One Desktop running Mac OS X v 10.6.8.

Syncing with iOS 10 on the Mac requires the latest version of iTunes, 12.5.1, and at least OS X 10.9.5. This would explain you receiving the invalid response error.

3 years later, and I'm having the same problem with my brand new iPhone 7. I'm on a Mac, iTunes is updated…and it just simply doesn't work. So frustrated.

uninstall the iTunes from laptop and it is done. 100% works

uninstall the iTunes from laptop and reinstall it and it is done. 100% works. Happened with me after upgrading to ios 10

Did you read my post above yours? DO you have iTunes 12.5.1 installed? It requires OS X 10.9.5 or above.

I updated the iMac's OS X to El Capitan and it solved the issue. Thanks for the help.

You're welcome.

I updated both my iPhone 6 and iPad Air 2 to iOS 10.0.2 and both devices are now not recognized by iTunes 12.1.2 (currently newest version) on my Windows 7 PC. I tried connecting my brother's iPad Air 1 with iOS 9.3.5 and that one was detected by iTunes normally. So I'm stuck with both my iOS 10.0.2 devices and can't do work on them in iTunes. This is terrible.

Perplexer- wrote:

iTunes 12.1.2 (currently newest version) on my Windows 7 PC.

That is not correct. The latest version of iTunes is 12.5.1. If you open iTunes, go to Help>Check for Updates. If it will not show that one is available, go to Control Panel, Programs, and see if you can repair Apple Software Update. If not, then you are going to have to remove iTunes and then reinstall from the iTunes download page. This is a glitch in Windows. See this ASC User provided tip for additional information for troubleshooting iTunes and Windows. Troubleshooting issues with iTunes for Windows updates Follow the instructions in the link provided for removing and then reinstalling iTunes.

I did that and it doesn't offer me any newer version. Will try the "repair" thing.