An invalid response was received from the device?

iTunes 12.5 requires OS X 10.9.5 or higher or Windows 7 or higher. You can download it from iTunes.com.

Ok, Check for Update from within iTunes didn't offer me any new version and "repairing" Apple Software Update didn't do anything either. So I went and downloaded the Setup for iTunes manually from Apple's website and installed it over my existing iTunes 12.1.2 installation. That went good and the new iTunes 12.5.1.21 now recognizes my iOS 10.0.2 devices.

Good to hear, but normally installing software in the manner that you did does not produce good results in Windows.

I had the same problem, I was trying to connect my iPhone 5s (iOS 10) to my Macbook Pro (OS X Mavericks).

It seemed like my iTunes version was pretty old for my phone's operating system, which was up to date.

~ Try updating iTunes to the latest version and try reconnecting the phone

This worked for me. Hope it works for you too.

A useless and insulting response. I just upgraded my iPhone to iOS 10.0.2. It was working perfectly until the update. Now it will not sync with iTunes nor will it load photos into iPhoto.

i have an Iphone 6 and the latest ios 10.0.2 and a Imac computer and it says as soon as i connect my phone to the imac Itunes could not connect to the iphone"iphone" because an invalid response was received from the device. please help

Please take the time to read the entire thread. Information about this and the Mac has already been explained. More than likely you have the incorrect version of iTunes and Mac OS X.

The difficulty is with the error message, which points you to an error on the phone. It is not, it is an error on the laptop. try installing the latest itunes to your laptop, for me, it was as simple as that. Others have issues with their firewall or usb cable.

What do I do if I have an older Mac Book that will not run the latest OS-X and thus will not run the latest iTunes? Am I stuck buying a new computer? Is there any way I can roll my iPhone back to iOS 9 without using iTunes? Remember, now that I've made the mistake of allowing the phone to update to iOS 10 I CANNOT connect to the iTunes on my MacBook that I have ben using to back up and sync the phone.

No. You can not downgrade iOS.

If your Mac isn't capable of running OS X 10.9.5 or higher, you can install Windows 7 or higher using boot camp or virtualization, install iTunes for Windows, and sync with that.

I also am having this issue with a new iPhone7 i just purchased today. My wife and I both backed up our IPhone6s on our respective computers (both mac) and proceeded to restore our new phones off of the old backup. My computer/phone combination worked perfectly, however my wife's computer will not connect to her new iPhone7 and displays the same message as the original post. I plugged my new iPhone7 into her computer with success. Also switched ISB ports and cables. As both of our phones are brand new as of today (and mine is recognized by her computer perfectly) there is some software issue with the phone. What's the solution?

Man I'm so tired of Apple blaming everything else. ALL my USB ports WORK with EVERYTHING ELSE. My charge cable WORKS! My iPhone WORKS! My PC WORKS! My software is UP TO DATE! My iTunes is UP TO DATE! Stop blaming everything else. I'm not going to use a different computer or reinstall iTunes or reinstall Windows or do a rain dance on a Sunday at 3.00pm when Jupiter is aligned with Saturn. THIS IS NOT MY PROBLEM TO SPEND TIME FIXING!

Me too. Do not believe everyone saying its a USB fault

Since updating to 10.0.2 my partners iPhone 6 will no longer connect to iTunes so unable to sync. My iPhone 5S works fine on the same usb cable in the same usb port.

I have deleted lockdown folders - no change

I have uninstalled and reinstall iTunes (currently upto date) - no change

We have just purchased an iPhone 7, and now cannot back up the iPhone 6 to transfer the data across.

Great.

spiltmonkeez wrote:

Since updating to 10.0.2 my partners iPhone 6 will no longer connect to iTunes so unable to sync. My iPhone 5S works fine on the same usb cable in the same usb port.

And what version of iTunes are you running? iOS 10 requires iTunes 12.5.1 or higher.

Is your 5s, which is working, running iOS 10?

Hello All

I am using Mac , tested USB cable and still it wont sync ! I have OS X 10.6.8 and trying to sync Iphone 6

still think it's related to IOS 10