I have the same issue, without having found the root cause. It seems a bit better with the latest update, but completly hung up again after starting Safari.
Problem description:
MacOS can quickly gets very slow after startup. Seems a bit better after latest update, but PC often hangs up and I need to restart. Happened again just now after starting Safari.
EtreCheck version: 2.1.6 (109)
Report generated 25 January 2018 at 14:18:30 CET
Download EtreCheck from http://etresoft.com/etrecheck
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Hardware Information: ℹ
iMac (27-inch, Late 2012) (Technical Specifications)
iMac - model: iMac13,2
1 3.4 GHz Intel Core i7 CPU: 4-core
32 GB RAM Upgradeable
BANK 0/DIMM0
8 GB DDR3 1600 MHz ok
BANK 1/DIMM0
8 GB DDR3 1600 MHz ok
BANK 0/DIMM1
8 GB DDR3 1600 MHz ok
BANK 1/DIMM1
8 GB DDR3 1600 MHz ok
Bluetooth: Good - Handoff/Airdrop2 supported
Wireless: en1: 802.11 a/b/g/n
Video Information: ℹ
NVIDIA GeForce GTX 680MX - VRAM: 2 GB
iMac 2560 x 1440
System Software: ℹ
macOS 10.13.3 (17D47) - Time since boot: 0:2:29
Disk Information: ℹ
APPLE HDD ST3000DM001 disk1 : (3 TB)
EFI (disk1s1) <not mounted> : 210 MB
Recovery HD (disk1s3) <not mounted> [Recovery]: 650 MB
Macintosh HD (disk2) / : 3.11 TB (1.01 TB free)
Core Storage: disk0s2 120.99 GB Online
Core Storage: disk1s2 3.00 TB Online
APPLE SSD SM128E disk0 : (121.33 GB)
EFI (disk0s1) <not mounted> : 210 MB
Boot OS X (disk0s3) <not mounted> : 134 MB
Macintosh HD (disk2) / : 3.11 TB (1.01 TB free)
Core Storage: disk0s2 120.99 GB Online
Core Storage: disk1s2 3.00 TB Online
WDC WD30EFRX-68AX9N0 disk3 : (3 TB)
EFI (disk3s1) <not mounted> : 210 MB
disk3s2 (disk3s2) <not mounted> : 3.00 TB
Boot OS X (disk3s3) <not mounted> : 134 MB
WDC WD30EFRX-68AX9N0 disk4 : (3 TB)
EFI (disk4s1) <not mounted> : 210 MB
disk4s2 (disk4s2) <not mounted> : 3.00 TB
Boot OS X (disk4s3) <not mounted> : 134 MB
USB Information: ℹ
Apple Inc. FaceTime HD Camera (Built-in)
Apple Inc. BRCM20702 Hub
Apple Inc. Bluetooth USB Host Controller
Canon MG6300 series
Apple Inc. MacBook Air SuperDrive
Thunderbolt Information: ℹ
Apple Inc. thunderbolt_bus
Western Digital My Book Thunderbolt Duo
Gatekeeper: ℹ
Mac App Store and identified developers
Kernel Extensions: ℹ
/Applications/zoom.us.app
[not loaded] zoom.us.ZoomAudioDevice (1.1 - SDK 10.8) [Support]
/Library/Application Support/Citrix Receiver
[not loaded] com.citrix.kext.gusb (12.4.0 - SDK 10.9) [Support]
/Library/Extensions
[not loaded] com.f-secure.kext.fsauth (1.0.0d1 - SDK 10.9) [Support]
[not loaded] com.movavi.driver.SoundGrabber (1.6.5 - SDK 10.9) [Support]
/System/Library/Extensions
[not loaded] com.devguru.driver.SamsungComposite (1.4.31 - SDK 10.6) [Support]
/System/Library/Extensions/ssuddrv.kext/Contents/PlugIns
[not loaded] com.devguru.driver.SamsungACMControl (1.4.31 - SDK 10.6) [Support]
[not loaded] com.devguru.driver.SamsungACMData (1.4.31 - SDK 10.6) [Support]
[not loaded] com.devguru.driver.SamsungMTP (1.4.31 - SDK 10.5) [Support]
[not loaded] com.devguru.driver.SamsungSerial (1.4.31 - SDK 10.6) [Support]
Problem System Launch Agents: ℹ
[loaded] com.openssh.ssh-agent.plist [Support]
Problem System Launch Daemons: ℹ
[not loaded] org.ntp.ntpd-legacy.plist [Support]
Launch Agents: ℹ
[not loaded] com.adobe.AAM.Updater-1.0.plist [Support]
[running] com.adobe.AdobeCreativeCloud.plist [Support]
[failed] com.adobe.ARMDCHelper.cc24aef4a1b90ed56a...plist [Support]
[running] com.canon.MFManager.plist [Support]
[running] com.citrix.AuthManager_Mac.plist [Support]
[running] com.citrix.ReceiverHelper.plist [Support]
[running] com.citrix.ServiceRecords.plist [Support]
[running] com.ctera.agentui.plist [Support]
[running] com.f-secure.fsmac.gui.plist [Support]
[loaded] com.f-secure.relauncher.plist [Support]
[loaded] com.f-secure.trasher.plist [Support]
[loaded] com.microsoft.update.agent.plist [Support]
[loaded] com.oracle.java.Java-Updater.plist [Support]
[not loaded] com.teamviewer.teamviewer.plist [Support]
[not loaded] com.teamviewer.teamviewer_desktop.plist [Support]
[invalid?] com.wdc.WD-Sync-Service.plist [Support]
Launch Daemons: ℹ
[loaded] com.adobe.acc.installer.plist [Support]
[running] com.adobe.agsservice.plist [Support]
[loaded] com.adobe.ARMDC.Communicator.plist [Support]
[loaded] com.adobe.ARMDC.SMJobBlessHelper.plist [Support]
[loaded] com.adobe.fpsaud.plist [Support]
[loaded] com.citrix.ctxusbd.plist [Support]
[loaded] com.cocoatech.pathfinder.SMFHelper6.plist [Support]
[loaded] com.cocoatech.pathfinder.SMFHelper7.plist [Support]
[running] com.ctera.agent.plist [Support]
[loaded] com.f-secure.fsavd-suppressor.plist [Support]
[loaded] com.f-secure.fsavd.dbhelper.plist [Support]
[failed] com.f-secure.fsavd.plist [Support]
[loaded] com.f-secure.fscsafeadmind.plist [Support]
[loaded] com.f-secure.fsmac.firewall.plist [Support]
[loaded] com.f-secure.fsmac.fsupdated_guts2.plist [Support]
[loaded] com.f-secure.fsmac.guts2downloader.plist [Support]
[loaded] com.f-secure.fsmac.licensetool.plist [Support]
[running] com.f-secure.orspclient.plist [Support]
[running] com.f-secure.urlexceptiond.plist [Support]
[running] com.fitbit.galileod.plist [Support]
[loaded] com.microsoft.autoupdate.helper.plist [Support]
[loaded] com.microsoft.office.licensing.helper.plist [Support]
[loaded] com.microsoft.office.licensingV2.helper.plist [Support]
[loaded] com.oracle.java.Helper-Tool.plist [Support]
[loaded] com.teamviewer.Helper.plist [Support]
[not loaded] com.teamviewer.teamviewer_service.plist [Support]
[invalid?] com.wdc.WDPrivilegedHelper.plist [Support]
User Launch Agents: ℹ
[loaded] com.adobe.AAM.Updater-1.0.plist [Support]
[invalid?] com.amazon.cloud-player.plist [Support]
[running] com.amazon.music.plist [Support]
[loaded] com.dropbox.DropboxMacUpdate.agent.plist [Support]
[invalid?] com.google.Chrome.framework.plist [Support]
[invalid?] com.parallels.mobile.startgui.launchagent.plist [Support]
[invalid?] com.skype.skype.shareagent.plist [Support]
[running] com.spotify.webhelper.plist [Support]
[invalid?] jp.co.canon.Inkjet_Extended_Survey_Agent.plist [Support]
User Login Items: ℹ
KiesAgent Application Hidden (/Applications/Kies.app/Contents/MacOS/KiesAgent.app)
WDDriveUtilityHelper Application (/Applications/WD Drive Utilities.app/Contents/WDDriveUtilityHelper.app)
fuspredownloader Application Hidden (/Users/[redacted]/Library/Application Support/.FUS/fuspredownloader.app)
Path Finder Application (/Applications/Path Finder.app)
fuspredownloader Application Hidden (/Users/[redacted]/Library/Application Support/.FUS/fuspredownloader.app)
WDSecurityHelper Application (/Applications/WD Security.app/Contents/WDSecurityHelper.app)
iTunesHelper Application (/Applications/iTunes.app/Contents/MacOS/iTunesHelper.app)
WD App Manager Application (/Applications/WD App Manager/WD App Manager.app)
Internet Plug-ins: ℹ
o1dbrowserplugin: Version: 5.4.2.18903 [Support]
Flip4Mac WMV Plugin: Version: 3.2.0.16 - SDK 10.8 [Support]
AdobeAAMDetect: Version: 3.0.0.0 - SDK 10.9 [Support]
FlashPlayer-10.6: Version: 28.0.0.137 - SDK 10.12 [Support]
AdobePDFViewerNPAPI: Version: 17.012.20098 - SDK 10.11 [Support]
Silverlight: Version: 5.1.41212.0 - SDK 10.6 [Support]
QuickTime Plugin: Version: 7.7.3
Flash Player: Version: 28.0.0.137 - SDK 10.12 [Support]
CitrixICAClientPlugIn: Version: 12.4.0 - SDK 10.11 [Support]
googletalkbrowserplugin: Version: 5.4.2.18903 [Support]
AdobePDFViewer: Version: 18.009.20050 - SDK 10.11 [Support]
SharePointBrowserPlugin: Version: 14.7.7 - SDK 10.6 [Support]
EPPEX Plugin: Version: 10.0 [Support]
JavaAppletPlugin: Version: Java 8 Update 144 build 01 Check version
User internet Plug-ins: ℹ
Picasa: Version: 1.0 - SDK 10.4 [Support]
ZoomUsPlugIn: Version: 4.1.11049.1024 - SDK 10.12 [Support]
Safari Extensions: ℹ
Evernote Web Clipper [Installed]
Browsing protection [Installed]
3rd Party Preference Panes: ℹ
Flash Player [Support]
Flip4Mac WMV [Support]
Safe Anywhere Mac Settings [Support]
Java [Support]
MusicManager [Support]
Time Machine: ℹ
Skip System Files: NO
Mobile backups: OFF
Auto backup: YES
Volumes being backed up:
Macintosh HD: Disk size: 3.11 TB Disk used: 2.09 TB
Destinations:
WD 3 TB RAID 1 [Local]
Total size: 3.00 TB
Total number of backups: 83
Oldest backup: 2016-08-30 05:15:55 +0000
Last backup: 2018-01-15 17:30:30 +0000
Size of backup disk: Too small
Backup size 3.00 TB < (Disk used 2.09 TB X 3)
TimeMachineBackup [Network]
Total size: 5.89 TB
Total number of backups: 52
Oldest backup: 2017-04-15 18:39:04 +0000
Last backup: 2018-01-25 10:46:08 +0000
Size of backup disk: Too small
Backup size 5.89 TB < (Disk used 2.09 TB X 3)
Top Processes by CPU: ℹ
37% firefox
25% plugin-container
5% WindowServer
1% mds
1% backupd
Top Processes by Memory: ℹ
1.61 GB Adobe Lightroom Classic
845 MB firefox
481 MB mds_stores
241 MB plugin-container
206 MB WindowServer
Virtual Memory Information: ℹ
23.67 GB Free RAM
6.91 GB Active RAM
1.64 GB Inactive RAM
2.15 GB Wired RAM
3.00 GB Page-ins
0 B Page-outs
Diagnostics Information: ℹ
Jan 25, 2018, 02:16:32 PM Self test - passed
Jan 24, 2018, 09:37:17 PM /Library/Logs/DiagnosticReports/Adobe Lightroom Classic_2018-01-24-213717_[redacted].cpu_resource.diag [Details]