Apple,
It MUST be clear now that this is a MAJOR embarrassment and problem.
Nearly every day, and sometimes multiple times in a day my mouse and/or keyboard drop out. I have to plug the keyboard in and connect a wired mouse in order to then reset Bluetooth. For many, this is not possible, so they have to tediously restart their Mac.
I do not believe this ever happened with my 2010 iMac for the last 7+ years.
I have no USB devices plugged in. No devices nearby that might interfere.
As the person I am replying to clearly states, this is an OS problem. You have degraded the base OS many times as you add new frills. What point multiple desktops if rebooting now loses the assignment of apps to those desktops? The devil is in the detail, but the detail you are now missing is a deep problem.
The Apple help line were friendly but actually believed that a device switched off would stop interfering with Bluetooth if I moved it further away. The Apple store in town still believe they can fix the problem - they would have me bring in my Mac - not so easy without a car I can assure you - and look at the problem. Even though I explained that it was intermittent - minutes or days between occurrences.
You MUST act on this as a severity 1 problem.
Your reputation is in serious jeopardy.