How to Block or Disable USB Port on Mac Sierra

Dear Experts,

Could you please help me block or disable USB ports in Mac sierra.

I followed both the methods but still not working.Kindly provides the solution to a block or disable USB.

Method 1

To remove kernel extensions for specific hardware

OUSBMassStorageClass.kext

Method 2

cd /System/Library/Extensions/

sudo kextload IOUSBMassStorageClass.kext