Safari preferences won't stick
I'm setting up a new-to-me MacBook, running on High Sierra. I went through the software update yesterday. I've been trying to set the preferences for Safari, but they keep reverting when I quit the app and reopen it. Things that consistently disappear are my homepage (reverts to Apple), search engine choice, toolbar customizations, and add-ons. Is there some plist file I need to delete. Do I need to reinstall Safari?
MacBook Pro, macOS High Sierra (10.13.6)