I can only speak for the iPhone 8 and 6S, but 12.6.4.3 works just as it
always has before iOS 12 and wasn't aware of the 12.6.5.3 update.
I did the iOS upgrade on the iPhone 8 on a different machine running
iTunes 12.8 and got the software update message if that means anything.
The phone also reconnected to that machine after the iOS upgrade and
the software update.
Why Apple would release a 12.9 version for Windows but not for Mac is
kind of puzzling. Also, waiting for Mojave to be released doesn't make
a lot of sense either if 12.9 is supposed to be used by earlier macOS
versions. But, I guess they have their reasons.