I too have this problem. Regularly I get spinning beach balls when trying to print, requiring me to force-quite the application, go to the Printers & Scanners prefs pane, reset the printing system and then reinstall the printers.
The advance give-away that this problem has occurred again is that launching applications (such as Word or Adobe Illustrator) suddenly takes very much longer.
Something is causing the printing system to get corrupted, but now that Console only shows you logs from the point at which you launch it, I cannot look back to see what might have caused this problem.