several Kernel Panics on Imac 5k

Sophos Antivirus is not the Problem on this issue,i think?

Reinstall your MacOS from the App Store,or from your Time Machine Copy,if you have some one?

You have still App Cleener,and Little Snitch,on your Mac!

Uininstall them from their web sites.

The Etrecheck Report will say the same like me,with,the issue on App Cleaner,and Little Snitch,or Sophos,if it still there?

The best way to solve,your, "Kernel Panics",is Reinstall your MacOS!

This one is pretty simple, you installed Sophos antivirus which at best is 100% worthless and at worst damaging to Mac OS. Mac OS is extremely secure and if simply kept up-to-date it will remain so. Mac OS does not benefit in any way from any third party antivirus, cleaning or any other third party maintenance apps. Mac OS is extremely elegant in that it has all the tools it needs within itself.

Please locate the developers instructions for uninstalling Sophos and uninstall it. Then restart in Safe Mode per https://support.apple.com/en-us/HT201262 and then restart normally and enjoy your Mac.

Per the KP report you provided, Sophos is still installed hence my posting. In order for us to help you we need to know what is installed on the computer. This will not show only confidential information and and is a pretty standard test we use when troubleshooting possible software problems. Please do the following so we can get a clear idea of what is installed on the system:

Please navigate to the Mac App Store and download the free version of EtreCheck OR please click www.EtreCheck.com where you will find the app. Once you downloaded the free app and created the report please post it as your reply to this message. In order to post it, please use the following link for more detailed instructions on how to correctly include the results: 

https://discussions.apple.com/docs/DOC-250000211

We can then look for obvious issues that may be causing your problem.