Kernel Panic after upgrade to 10.15.1

Mac Pro 2013 and LaCie Thunderbolt 3 raids : MacPanic; MacMini (came in monday) with Lacie Thunderbolt 3 raids : MacPanic. I spend more than 4 x 1hr with level 2 tech in Montréal and i believe they are not aware of the problem... nor of any shadow of a solution. It happened With Catalina 15.0, 15.1 and 15.2. Will try no sleep solution...

I turned off the automatic screen saver (In "Desktop & Screen Saver" I set the "Start after:" setting to "Never") and have not had a kernel panic crash in over a day. Looks like there may be some hiccup between the Apple screen saver and Thunderbolt attached storage.

Lucky you : catalina 10.15.0 or 10.15.1 ou 10.15.2 = s.s.d.d. Solutions like no sleep for the hard drive or no screen savers are like a plaster on a wooden leg... it is like cutting the water supply to make sure the electricity supply will work... service tech at Apple told me to be happy to use those solutions. I told him they need to fix the problem. I had problems with Catalina an with its predessessor. From now on I will wait at least 6 months before downloading a new O.S. I understand well that every possible situation cannot be tested before roll-out but external HD on Thunderbolt 3 is very not uncommon...

Macmini 2018 running 10.15.2 almost constant kernel panics. So far the only solution was to disconnect both my Thunderbolt 2 external drive (connected with Apple thunderbolt 3 adapter) and my USB 3 external drive. I didn't change any power or sleep settings but since disconnecting the drives no more panics. I connected both drives to another mac running High Sierra, no panics.

So another update. Yesterday I installed 10.15.3 beta (through 10.15.0) on an external drive cleanly and went through the day with my thunderbolt drives no problem. This morning I'm upgrading my main Mojave install to 10.15.3 beta (again, with 10.15.0 in between) and so far it seems stable. Crossing fingers....

You're not the only one.

I bought a 5k$ Mac mini in 2018 and put together a Windows PC early 2019 as well after 18 years of using Mac only.

I bought 2 iPhone 11Pro Max last year, one for me and one for my wife.

With all the serious problems I'm having that Apple neglects to resolve and the useless support (clean install is the only answer these "Geniuses" have) I'm seriously considering to sell my Mac and iPhones, continue with my PC and get me two Samsung Galaxy Note 10 Plus.

Applying the 10.15.3 combo update appears to have worked for me.

My 16-inch MacBook Pro, with Thunderbolt drive attached, has slept and been woken multiple times over the last six hours, and no kernel panics.

I'll update this thread if I see any more panics.

Been over 2 days now and still no panics at all from sleep/reboot/restart or whatever.

Also Time Machine keeps working to Synology NAS where before it wanted to create a complete new backup whenever it started.

On a 2018 Mac Mini with lots of TB3 and USB attached.

@ClaudeG77 : What if you try to do the combo update of 10.15.3 over 10.15.3?

Yes, that's true, and some people just update with the 10.15.3 combo and all is OK. However these kernal panics have many causes and some of these "crash threads" can get to 80 pages long trying to solve 10 different causes with just one remedy. You need to try them all unless you can read KPs intelligently.

You said. "...Nothing worked..."

Yes it did!! you changed users to fix it, so there is something corrupt in your old user account. Probably easier to ignore the old account and move on with the new one.

Often fixes many many problems.

There are two additional updates to Catalina since 10.15.1. Download and apply the macOS Catalina 10.15.3 Combo Update. 

just sharing the latest settings, which worked a bit.

The Endpoint Security kext is provided by Apple as part of the Catalina install.

How do you uninstall it?