Same here. Brand new MBP 16-inch base model.
Happens on YouTube in Safari when skipping around the video, or when closing the tab that's playing the video. Pops come randomly out of the left or right speaker whenever the sound is stopped abruptly. Doesn't happen when skipping around an MP4 video in QT Player. Doesn't happen when playing music in Spotify and skipping around - but it does happen in Spotify if I stop the sound abruptly by closing the lid or plugging in headphones.
Another reliable way to reproduce: Utilities > Audio MIDI Setup > MacBook Pro Speakers > Configure Speakers > click either of the Test buttons in the bottom right corner of the window. You'll (usually) hear a click after the test noise stops.
Would be great to know if this is hardware or software related. I'm assuming it's a driver issue at this stage.
BTW there are other reports of this issue with the 16-inch appearing at the end of this thread on the 2019 15-inch model:
https://discussions.apple.com/thread/250758649?page=3