From the report:
" Unsigned files - There are unsigned software files installed. These files could be old, incompatible, and cause problems. They should be reviewed.
System modifications - There are a large number of system modifications running in the background.
x86-only Apps - This computer has x86-only apps might not work on future versions of the operating system.
Limited drive access - More information may be available with Full Drive Access.
Kernel extensions present - This computer has kernel extensions that may not work in the future."
Please try to cleanup.
Intego Backup Assistant Agent 0 (INTEGO)
LDM 0 (Not signed - /Applications/LaCie Desktop Manager.app)
I use a Mac with similar configuration and a LaCie external drive from Apple store for Backup.
But I use it with Time Machine.
You could try removing these files and see what happens if you are not actively using those applications .