I ended my testing and twiddling with High Sierra 10.13.2 about a week ago. Why? For the time being I've had no more problems and it's running like it's supposed to on my Mac Pro 5,1. Not to say I've found the complete cure but just some observations from my end..
High Sierra is the FASTEST system on a Mac I've ever had after running it between two brand new Crucial SSD drives for a week. I'm sure there are other SSD drives that play well with High Sierra including Apples new OEM drives.
The Mac Pro is a good drive test platform inasmuch with four drive bays you can hot swap drives to your liking and it's enlightening when you’ve had problems with High Sierra as most of us have. I believe IMO that certain SSD brand drive configurations, firmware, internal or external are creating the majority of the High Sierra problems.
More by accident, not by design in my case I've found that any SSD drive that is polled by the system or all non compatible SSD drives active in the computer, boot drive or not will slow down High Sierra to a crawl or lock it up completely. The one early HFS drive in my system is still bootable and loaded as a backup in my system has given me no problems at all. I'm sure if I booted to this drive I'd probably run out of coffee before it loaded tho...
At any rate I believe it's come down to SSD drive choices, firmware in the drives, etc due to the APFS file system. And it doesn’t matter if a drive is the active boot drive or not, just ANY SSD flash drive being polled in the system will mess up High Sierra as I've found with one OWC SSD drive that High Sierra actually unmounted in the background as it was causing problems. After the idle SSD drive unmounted (on it's own) only a complete restart would bring HS back to normal.
I'm going to stick with Sierra on our 2015 Mac Book Pro for now as we have no way to save it's data and swap to another compatible SSD drive at the moment.. It seems Apple has put a "no comment no information" regarding High Sierra for the time being.. IMO, when Apple finally comments APFS flash drive compatibility will be the main subject..