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See this article macOS Sierra: Erase and reinstall macOS

After that don't install third party applications / softwares , any apps like clean my Mac , anti virus , try to keeps extensions as off , in users and groups keep login items as empty .

A clean install is actually fairly simple, although it takes some time.

Boot to the Recovery Volume (command - R on a restart). Run Disk Utility/First Aid. Reformat the drive using Disk Utility/Erase. Reformat the drive using Disk Utility/Erase. Use Mac OS Extended (Journaled), then click the Option button and select GUID. Quit Disk Utility, then re-install the OS.

OS X Recovery

OS X Recovery (2)

Once you have done that, follow babowa's advice regarding copying over documents and reinstalling applications. Fresh installs of most applications usually provides the best results.

One issue that I see is that your Mac is running numerous daemons, agents, and Internet plug-ins and Safari extensions. Are you sure you really need them all?

Regardless, I would suggest removing the following from your Mac:

1. TechTool Pro
2. CleanMyMac 2
3. Mac Cleanser
4. Silverlight
5. Multiple ad blocking plug-ins. I suggest that you choose one or use none at all.

Additionally, you may want to consider performing a complete Time Machine backup and a clone of your Mac's drive. Then perform a clean install of macOS. Run your Mac or a few days to see if this help. It should. Then add back just those applications, plug-ins, etc. that you really need.

Suggest you also uninstall CleanMyMac 3.

You have so much 3rd party software installed that is supposed to 'protect' your computer, I'm not surprised you have performance problems. The below are some examples.

[Not Loaded] DeviceSentry.kext (5.1 (710))

[Not Loaded] DeviceSentryCR.kext (5.1 (710))

[Not Loaded] NetBlockade.kext (5.1 (710))

[Not Loaded] NetworkSpyAlert.kext (5.1 (710))

I agree with the above suggestion for a clean install and I suggest you install the minimum required 3rd party software.

The OS has built in software protection and all your 3rd party protection software interferes with normal operation.

Along with the suggested removals (no one needs that many Safari extensions), CleanMyMac and all other such garbage apps are known to remove files they shouldn't. You know. Unimportant stuff like system files.

Once you remove the garbage from your Mac, reinstall the OS.

SuperDuper! doesn't work that way. If you do a clean install and then use SD to copy/clone the external drive back, you will end up back where you started from. System files that may have been removed by CleanMyMac will be gone again since that's what SD is supposed to do - match the target drive to the source. It will change, add or remove files as necessary to achieve that goal.

Complicated apps such as Photoshop can't be simply dragged from one Application folder to the other. There a lot of other files and folders it installs. Many not that obviously named.

Installing the OS on an erased drive and then adding all of your third party apps from their original source disks or purchased downloads is certainly the best way to go for an overall squeeky clean drive. It's just time consuming to do all of that. And, you have the external clone to use as your regular drive while you rebuild the internal.

But, if you want to try speeding up the process, once you have your external clone and you've tested to make sure it's bootable, startup to the normal drive again, dismount and turn the external drive off. Do as much cleanup as you can per what's been mentioned above, then reinstall the OS from Recovery mode. Still a fair amount of work, but a lot less time than an entire rebuild if you have a lot of apps to reinstall, plus bringing all of your data back in, such as your emails, settings and other documents.

The erase and reinstall the OS is a good start, but reinstalling applications from the clone may or may not work. Applications that are self contained (all parts of the application are contained when you copy over the application) will work. Some 3rd party applications may have to be installed from scratch. Since you aren't restoring the full clone, some applications have files in parts that aren't being restored.

Really! Reinstalling applications like Microsoft Office will damage the system files and OS? I didn't know that. If I reinstall Adobe Acrobat Pro, that will damage system files and the OS? If I install the latest version of Quicken, that will damage system files and the OS? Based on what you posted, no third party software can be installed. Apple should shut down the App Store based on what you posted.

Microsoft is a genuine source , and if the user has purchased the licensed version from renowned apple store then its ok ( App Store applications are all outsourced and these apps can be broken or not compatible with Mac ) , I can not speak more about it .

Yes " always "if the user wants the Mac to be trouble free no third party apps in Mac .

I'm sorry but that sounds a bit too extreme. Even Apple will recommend some third party apps. And, third party software is mentioned in the SLA. As well, I've run third party software for years without a single problem.

Hello !

They only recommend Malwarebytes anti malware for Mac , some times Microsoft but never implement ( discussed with apple support senior advisors many times for third party apps answer was no and after that its up to the user ) , I am just a Mac user here .

Any senior advisor who suggests such a thing is, bluntly, an idiot.

If we're supposed to take that at face value, then let's start out by saying you will have to stop using your Mac entirely since what's underneath the GUI is (a now heavily modified version) of the open source BSD Unix OS. So, the entire OS is built on top of "third party" software.

What about the CPU and its support chips, or the firmware in your SSD and graphics controller? Apple didn't write a single line of code for any of those. Does that make them untrustworthy?

I do prepress work for a living. What does Apple have that would do the same work I can accomplish in Photoshop? Hmm. The only item would be Preview. Laughably useless in comparison. Page layout? All Apple has is Pages, which is a cross between a word processor and a page layout app. It's most glaring downfall? It doesn't understand CMYK - at all. Any such image you drop into Pages is automatically converted to RGB. Totally, 100% useless app for the printing industry. We'll work with Pages documents when they're sent to us, but the first thing we do is convert them to InDesign or Quark XPress (there's them darn third party apps again!).

Oh, and delete just about all of the fonts installed by the OS. Most are supplied by Bitstream, Microsoft, and other third party vendors.

This list could go on for pages and barely scratch the surface of very usable and essential third party apps there are no Apple alternatives for. Basically, you're saying I shouldn't get any work done. Or, take the hardest, slowest way around as possible to do something, if you can do it at all.

Sorry, but that is ridiculous. Of course, Apple will maintain that it may be best to run only Apple apps - why?

Because Apple's SLA is worded such that they are not responsible for any mishaps to software - it is the consumer's responsibility. And, support will not help with third party apps since one cannot know for certain if it is that app's problem or not and they are not proficient with that app.

And don't forgot you're not allowed to use the macOS to operate a nuclear facility, or create nuclear weapons with it. 🙂

E. YOU FURTHER ACKNOWLEDGE THAT THE APPLE SOFTWARE AND SERVICES ARE NOT INTENDED OR SUITABLE FOR USE IN SITUATIONS OR ENVIRONMENTS WHERE THE FAILURE OR TIME DELAYS OF, OR ERRORS OR INACCURACIES IN THE CONTENT, DATA OR INFORMATION PROVIDED BY, THE APPLE SOFTWARE OR SERVICES COULD LEAD TO DEATH, PERSONAL INJURY, OR SEVERE PHYSICAL OR ENVIRONMENTAL DAMAGE, INCLUDING WITHOUT LIMITATION THE OPERATION OF NUCLEAR FACILITIES, AIRCRAFT NAVIGATION OR COMMUNICATION SYSTEMS, AIR TRAFFIC CONTROL, LIFE SUPPORT OR WEAPONS SYSTEMS.

10. Export Control. You may not use or otherwise export or reexport the Apple Software except as authorized by United States law and the laws of the jurisdiction(s) in which the Apple Software was obtained. In particular, but without limitation, the Apple Software may not be exported or re-exported (a) into any U.S. embargoed countries or (b) to anyone on the U.S. Treasury Department’s list of Specially Designated Nationals or the U.S. Department of Commerce Denied Person’s List or Entity List or any other restricted party lists. By using the Apple Software, you represent and warrant that you are not located in any such country or on any such list. You also agree that you will not use the Apple Software for any purposes prohibited by United States law, including, without limitation, the development, design, manufacture or production of missiles, nuclear, chemical or biological weapons.