Trend Micro is part of the problem. ANY third-party anti-virus or security software will take a terrible toll on performance as it competes with the sophisticated protection Apple builds into its operating system. Same for any app that clams to "clean, optimize, or tune-up" your Mac. All that gets cleaned is your wallet. Removal instructions:
https://helpcenter.trendmicro.com/en-us/article/TMKA-14475
The elephant in the room is the slow, mechanical hard drive Apple insists on fitting to entry-level iMacs. Yours is slower than normal. possibly due to the massive dose TrendMicro stuff.
Performance:
System Load: 3.60 (1 min ago) 2.97 (5 min ago) 2.46 (15 min ago)
Nominal I/O speed: 5.75 MB/s
File system: 43.44 seconds
Write speed: 39 MB/s
Read speed: 38 MB/s
Those two I bolded should be in the 60-70 MB/sec range. If removing TrendMicro does not move those to the 60MB/se range then the drive is truly failing. There is a workabout for that model that will save you having to gut the computer to replace the old drive.